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FluTE, a Publicly Available Stochastic Influenza Epidemic Simulation Model

Identifieur interne : 000083 ( 1957/Analysis ); précédent : 000082; suivant : 000084

FluTE, a Publicly Available Stochastic Influenza Epidemic Simulation Model

Auteurs : Dennis L. Chao [États-Unis] ; M. Elizabeth Halloran [États-Unis] ; Valerie J. Obenchain [États-Unis] ; Ira M. Longini [États-Unis]

Source :

RBID : PMC:2813259

Descripteurs français

English descriptors

Abstract

Mathematical and computer models of epidemics have contributed to our understanding of the spread of infectious disease and the measures needed to contain or mitigate them. To help prepare for future influenza seasonal epidemics or pandemics, we developed a new stochastic model of the spread of influenza across a large population. Individuals in this model have realistic social contact networks, and transmission and infections are based on the current state of knowledge of the natural history of influenza. The model has been calibrated so that outcomes are consistent with the 1957/1958 Asian A(H2N2) and 2009 pandemic A(H1N1) influenza viruses. We present examples of how this model can be used to study the dynamics of influenza epidemics in the United States and simulate how to mitigate or delay them using pharmaceutical interventions and social distancing measures. Computer simulation models play an essential role in informing public policy and evaluating pandemic preparedness plans. We have made the source code of this model publicly available to encourage its use and further development.


Url:
DOI: 10.1371/journal.pcbi.1000656
PubMed: 20126529
PubMed Central: 2813259


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:2813259

Le document en format XML

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</record>

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